Evaluation of immunogenicity and tolerability of a live attenuated hepatitis a vaccine in Indian children.
نویسندگان
چکیده
An open non comparative study of a live attenuated H2 strain Hepatitis A vaccine of Chinese origin was carried out in 143 healthy Indian children aged 1 to 12 years (mean age 4.87 2.76 years; 88 boys, 55 girls). At baseline, all were negative for IgG HAV antibodies and had normal hematological and biochemical indices. Two months after a single dose of the vaccine (given subcutaneously), 137 children (i.e. 95.8 %) developed protective antibodies of IgG > 20 mIU / mL. The hematological and biochemical parameters remained within normal limits. There were no adverse events in any except mild fever in one child. In conclusion, live attenuated H2 strain Hepatitis A vaccine in a single dose was found to be immunogenic and safe in Indian children.
منابع مشابه
Long-term immunogenicity of single dose of live attenuated hepatitis A vaccine in Indian children.
OBJECTIVES To assess immunogenicity of a single dose of live attenuated hepatitis A vaccine in Indian children, ten years after immunization. METHODS Of 143 children vaccinated in 2004, 121 children were evaluated in 2014, clinically and for anti-HAV antibodies. RESULTS 13 children were early vaccine failures who received two doses of HAV vaccine subsequently. 106 (98%) of 108 remaining chi...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 43 11 شماره
صفحات -
تاریخ انتشار 2006